![]() ![]() (Search for linked caDSR metadata) (search value sets)Įxternal Source Codes: CAS Registry NumberĪdult patients with recurrent or metastatic cervical cancer. On this page you'll find 139 synonyms, antonyms, and words related to initiator, such as: assailant, intruder, invader, trespasser, instigator, and provoker. Expression of TF is correlated with metastasis, angiogenesis, tumor cell growth and tumor-associated thrombosis. TF, a transmembrane protein and initiator of the coagulation cascade, is overexpressed in many tumor cells and tumor-resident endothelial cells. It then binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and apoptosis. sulfones or alkynyl phenyl sulfones in the presence of a radical initiator. After internalization of the agent, the MMAE moiety is released by proteolytic cleavage. Synonym, catecholborane, 1,3,2-benzodioxaborole, benzo d 1,3,2 dioxaborole. This may prevent thrombin formation and cancer-associated venous thromboembolism, and may inhibit angiogenesis and tumor cell proliferation. Tisotumab binds to factor VIIa (FVIIa), which interferes with the activation of factor X (FX) into FXa. Upon administration of tisotumab vedotin, the tisotumab moiety binds to cell surface TF and is internalized. Synonyms for INITIATOR: founder, creator, inventor, author, father, originator, pioneer, generator Antonyms of INITIATOR: student, pupil, supporter. An antibody-drug conjugate (ADC) comprised of tisotumab, a monoclonal antibody against human tissue factor (TF) covalently coupled, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and potent microtubule disrupting agent, with potential antiangiogenic, anticoagulant and antineoplastic activities.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |